Research

A1

Molecular basis and evolutionary dynamics of C. elegans-microbiota interactions

The model nematode Caenorhabditis elegans is associated with a distinct microbial community under natural conditions. Yet, to date, the role of the worm’s microbiota for

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A2

Host-microbiota coevolution in the mammalian intestine

Understanding the forces that shape variation in host-associated bacterial communities within- and between host species is key to understanding the evolution and maintenance of metaorganisms.

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A3

Domestication-driven metaorganism evolution of wheat

Plants are colonized by a wide diversity of microbes including both eukaryotic and prokaryotic species. Only recently, metagenomic approaches have allowed exhaustive studies of the

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A4

Mathematical modeling of interactions in evolving metaorganisms

Why do individuals from different taxonomic groups and even kingdoms of life interact with each other within a metaorganism in a generally beneficial way and

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B1

Host-microbe cross talk in the early metazoan taxa Porifera and anthozoan Cnidaria

The term “metaorganism” was coined in recognition of the fact that in the environment, all multicellular hosts (animals, plants) associate with microorganisms. The concept has

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B2

Microbiota-host interactions at the base of the metazoan tree

This project addresses in a comparative approach the presence, establishment and functional consequences of microbiota in two basal metazoan animals, the comb jelly Mnemiopsis leidyi

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C1

Towards understanding an ultimately simple metaorganism: impact of symbiotic microbes and algae on developmental processes of Hydra and their adaption within the host

Inter-species interactions in the freshwater polyp Hydra between symbiotic algae and host cells had been the subject of research since decades since they not only

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C2

Effects of malnutrition on epithelia-microbe interactions in the intestinal tract of flies and mice

Maintaining the composition of the beneficial intestinal microbiota requires a homeostatic equilibrium between the microbial community and the intestinal epithelium that serves as the regulatory

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C3

The life cycle of the deep-sea Bathymodiolus metaorganism: symbiont transmission and colonization of the host gill epithelium

Chemosynthetic symbioses evolved independently multiple times in at least nine animal phyla and from at least 12 lineages of free-living bacteria. They were first discovered

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Z1

Administration and coordination of the CRC 1182

The main purpose of the Z1-project is to bundle the central activities of the Collaborative Research Centre 1182. The administrative office runs the daily affairs

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Z2

Microorganism: Culture and single cell analysis

The main purpose of the Z2-project is the development of a platform that allows the isolation and identification of microorganisms associated with animal and plant

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Z3

Next generation sequencing applications for studying metaorganisms

The main purpose of the Z3-project is to provide a standardized central hub for next generation sequencing(NGS)-based applications among CRC 1182 projects. This includes the

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INF

Data management and integrated analyses

The INF-project is established to support the demanding bioinformatic requirements of the CRC 1182. The project will develop data and metadata standards in order to

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