Prof. Dr. Andre Franke
Institution
Contact
Vita
Education/Training
2004 – 2006
PhD work at CAU under supervision of Profs. Stefan Schreiber: “A systematic genome-wide association analysis for inflammatory bowel diseases”
2002 – 2003
Diploma thesis at the laboratory of Prof. Thomas C.G. Bosch at CAU: “Development of a high-throughput screening for identification of developmentally regulated genes in Hydra”
1998 – 2002
Study of Biology and Informatics at CAU
Research Experience/Academic Appointments
Since 2016
W3 professorship of Molecular Medicine
Since 2011
Director of the Institute of Clinical Molecular Biology
2011 – 2016
W2 endowment professorship “Peter Hans-Hofschneider”of the Foundation of Experimental Biomedicine (Zuerich, Switzerland)
2011
Guest scientists at the Broad Institute of MIT and Harvard (Boston, USA) in the group of Mark J. Daly and mentored by Richard S. Blumberg
2008 – 2013
Academic guest professorship at the Medical Faculty, University of Oslo, Norway (Rikshospitalet)
2008 – 2011
W1 junior professorship for Epithelial Barrier Diseases within the DFG Cluster of Excellence “Inflammation at Interfaces”
Important Scientific Prizes/Functions
Since 2012
Spokesperson of the DFG Research Training Group GRK1743/1 “Genes, Environment and Inflammation”
Since 2012
Member of the Steering Committee of “Inflammation at Interfaces”; Leader of Research Area I (Genetics)
2017
Schleswig-Holstein Excellence Chair (8 professors in State selected)
2017
Thannhauser Prize of the DGVS
2012
Ludwig-Demling Research Prize of German Crohn’s and Colitis Foundation (DCCV); 25,000 €
2011
Janssen Prize Dermatology
2009 – 2012
Spokesperson of the young investigators of the Excellence Cluster “Inflammation at Interfaces”
2008
Hensel Prize (100,000 €) for Excellent Research of CAU Kiel
Research
Publications
2020
FeaturedA fungal pathogen induces systemic susceptibility and systemic shifts in wheat metabolome and microbiome composition
Seybold H, Demetrowitsch TJ, Hassani M A, Szymczak S, Reim E, Haueisen J, Lübbers L, Rühlemann M, Franke A, Schwarz k, H. Stukenbrock E (2020) Nature Communications. 11(1):1910. doi: 10.1038/s41467-020-15633-x
2019
FeaturedComparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms
Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen F-A, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019) Microbiome, doi: 10.1186/s40168-019-0743-1
Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis
Rühlemann M, Liwinski T, Heinsen F-A, Bang C, Zenouzi R, Kummen M, Thingholm L, Tempel M, Lieb W, Karlsen T, Lohse A, Hov J, Denk G, Lammert F, Krawczyk M, Schramm C, Franke A (2019) Aliment Pharmacol Ther. 1-10. doi: 10.1111/apt.15375
FeaturedAlterations of the bile microbiome in primary sclerosing cholangitis
Liwinski T, Zenouzi R, John C, Ehlken H, Rühlemann MC, Bang C, Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen TH, Hov JR, Rösch T, Lohse AW, Heeren J, Franke A, Schramm C (2019) Gut 0:1–8. doi:10.1136/gutjnl-2019-318416
2018
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.
Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P (2018); Genome Med. 10(1):27. doi: 10.1186/s13073-018-0534-5
The sponge holobiont in a changing ocean: from microbes to ecosystems.
Pita L, Rix L, Slaby B M, Franke A, Hentschel U (2018); Microbiome, 6(46). doi: 10.1186/s40168-018-0428-1
Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration
Baurecht H, Rühlemann M, Rodríguez E, Thielking F, Harder I, Erkens AS, Stölzl D, Ellinghaus E, Hotze M, Lieb W, Wang S, Heinsen FA, Franke A, Weidinger S (2018) J ALLERGY CLIN IMMUN . doi: 10.1016/j.jaci.2018.01.019
The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany.
Häsler R, Kautz C, Rehman A, Podschun R, Gassling V, Brzoska P, Sherlock J, Gräsner J T, Hoppenstedt G, Schubert S, Ferlinz A, Lieb W, Laudes M, Heinsen F A, Scholz J, Harmsen D, Franke A, Eisend S, Kunze T, Fickenscher H, Ott S, Rosenstiel P, Schreiber S (2018); Microbiome., 6(1):37. doi: 10.1186/s40168-018-0414-7
2017
Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.
Rühlemann M C, Degenhardt F, Thingholm L B, Wang J, Skiecevičienė J, Rausch P, Hov J R, Lieb W, Karlsen T H, Laudes M, Baines J F, Heinsen F A, Franke A (2017); Gut Microbes., 8:55. doi: 10.1080/19490976.2017.1356979
2016
FeaturedGenome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
Wang J, Thingholm L B, Skiecevičienė J, Rausch P, Kummen M, Hov J R, Degenhardt F, Heinsen F A, Rühlemann M C, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge R K, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan W H, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D’Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall H U, Lieb W, Nöthlings U, Karlsen T H, Baines J F, Franke A (2016); Nat Genet., 48(11):1396-1406. doi: 10.1038/ng.3695