Prof. Dr. Andreas Tholey
Institution
Contact
Vita
Education/Training
2007
Habilitation for Analytical Biochemistry, Saarland University
1999
Dr. rer.nat, Saarland University / DKFZ Heidelberg
1995
Dipl. Chem., Saarland University
1989 – 1995
Study of Chemistry, Saarland University, Saarbrücken
Research Experience/Academic Appointments
Since 2008
Group leader and W2-professor for Systematic Proteome Research & Bioanalytics at the Christian-Albrechts-University of Kiel (position originally funded via DFG-Cluster of Excellence “Inflammation at Interfaces”; now: permanent position)
2010
Guest-professorship at Université de Pau, France
2004
Research Stage at the “Laboratoire de Spectrometrie de masse Bio-Organique”, University of Strasbourg/ CNRS, Strasbourg, France
1999 – 2007
Postdoctoral fellow and Habilitation (C1), Saarland University
1995 – 1998
Scientific assistant, German Cancer Research Centre (DKFZ), Heidelberg
Important Scientific Prizes/Functions
Since 2012
Member of the Steering-Committee of the DFG-Cluster of Excellence-308 “Inflammation at Interfaces”
Since 2011
Vice-chair of initiative on multi-organism proteomics (iMOP) within human proteome organization (HUPO)
Publications
2019
FeaturedPrdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles
Lipinski S, Pfeuffer S, Arnold P, Treitz C, Aden K, Ebsen H, Falk-Paulsen M, Gisch N, Fazio A, Kuiper J, Luzius A, Billmann-Born S, Schreiber S, Nuñez G, Beer HD, Strowig T, Lamkanfi M, Tholey A, Rosenstiel P (2019) EMBO J. 38(20) doi: 10.15252/embj.2018101266.
The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life
Yang W#, Petersen C#, Pees B#, Zimmermann J, Waschina S, Dirksen P, Rosenstiel P, Tholey A, Leippe M, Dierking K, Kaleta C*, Schulenburg H*. Front Microbiol. 10:1793. # Equal contribution as first authors, * Equal contribution as senior authors doi: 10.3389/fmicb.2019.01793.
2018
The Caenorhabditis elegans proteome response to naturally associated microbiome members of the genus Ochrobactrum
Cassidy L, Petersen C, Treitz C, Dierking K, Schulenburg H, Leippe M, Tholey A (2018); Proteomics, doi: 10.1002/pmic.201700426
Miniaturized dispersive liquid-liquid microextraction and MALDI MS using ionic liquid matrices for the detection of bacterial communication molecules and virulence factors.
Leipert J, Bobis I, Schubert S, Fickenscher H, Leippe M, Tholey A (2018); Anal Bioanal Chem. , pp 1–12. doi: 10.1007/s00216-018-0937-6
2017
We Are Not Alone: The iMOP Initiative and Its Roles in a Biology- and Disease-Driven Human Proteome Project.
Tholey A, Taylor N L, Heazlewood J L, Bendixen E (2017); J Proteome Res., 16(12):4273-4280. doi: 10.1021/acs.jproteome.7b00408
Insights into Microalga and Bacteria Interactions of Selected Phycosphere Biofilms Using Metagenomic, Transcriptomic, and Proteomic Approaches.
Krohn-Molt I, Alawi M, Förstner K U, Wiegandt A, Burkhardt L, Indenbirken D, Thieß M, Grundhoff A, Kehr J, Tholey A, Streit W R (2017); Front Microbiol., doi: 10.3389/fmicb.2017.01941
Identification and Quantification of N-Acyl Homoserine Lactones Involved in Bacterial Communication by Small-Scale Synthesis of Internal Standards and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.
Leipert J, Treitz C, Leippe M, Tholey A (2017); J Am Soc Mass Spectrom., 28(12):2538-2547. doi: 10.1007/s13361-017-1777-x
FeaturedEfficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection. Gastroenterology.
Ott S J, Waetzig G H, Rehman A, Moltzau-Anderson J, Bharti R, Grasis J A, Cassidy L, Tholey A, Fickenscher H, Seegert D, Rosenstiel P, Schreiber S (2017); Gastroenterology, 152(4):799-811.e7. doi: 10.1053/j.gastro.2016.11.010
2016
Differential quantitative proteome analysis of Escherichia coli grown on acetate versus glucose.
Treitz C, Enjalbert B, Portais J C, Letisse F, Tholey A (2016); Proteomics., 16(21):2742-2746. doi: 10.1002/pmic.201600303
Combination of Bottom-up 2D-LC-MS and Semi-top-down GelFree-LC-MS Enhances Coverage of Proteome and Low Molecular Weight Short Open Reading Frame Encoded Peptides of the Archaeon Methanosarcina mazei.
Cassidy L, Prasse D, Linke D, Schmitz R A, Tholey A (2016)
J Proteome Res., 15(10):3773-3783. doi: 10.1021/acs.jproteome.6b00569