Principal Investigator

Prof. Dr. Matthias Leippe



Habilitation in Zoology at the University of Hamburg

PhD in Zoology

1987 – 1988
Civil Services

1984 – 1986
Studies for the PhD Thesis Zoological Institute, University of Hamburg

1977 – 1984
Study of Biology at University of Hamburg

Research Experience/Academic Appointments

since 10/2003
C4 Professor and Director, Zoophysiology, Zoological Institute, CAU

2001 – 2003
C3 Professor, Molecular Parasitology, University of Würzburg

1999 – 2001
Coordinator of the Research program `Amoebiasis´ of the institute

1992 – 1993
Guest scientist at the European Molecular Biology Laboratory (EMBL), Heidelberg

1989 – 2001
Researcher at the Bernhard Nocht Institute for Tropical Medicine, Hamburg; independent Group leader since 1993

Important Scientific Prizes/Functions

since 2007
Member of the Editorial Advisory board of Developmental and Comparative Immunology

2006 – 2014
Member of the Editorial Advisory board of the Biochemical Journal

2001 – 2004
Member of the Board of the Deutschen Gesellschaft für Parasitologie (DGP)

Karl Asmund Rudolphi medal of the Deutsche Gesellschaft für Parasitologie (DGP)

1997 – 2001
Fellowship of the Heisenberg Program of the Deutsche Forschungsgemeinschaft (DFG)

Award of the Deutsche Tropenmedizinische Gesellschaft (DTG)

Research award of the Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM)

Young Investigator Award, American Society of Tropical Medicine and Hygiene




FeaturedThe functional repertoire contained within the native microbiota of the model nematode Caenorhabditis elegans

Zimmermann J, Obeng N, Yang W, Pees B, Petersen C, Waschina S, Kissoyan KAB, Aidley J, Hoeppner MP, Bunk B, Spröer C, Leippe M, Dierking K, Kaleta C*, Schulenburg H* (2019) The ISME Journal. 1-13. * Shared senior authorship  doi: 10.1038/s41396-019-0504-y

The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life

Yang W#, Petersen C#, Pees B#, Zimmermann J, Waschina S, Dirksen P, Rosenstiel P, Tholey A, Leippe M, Dierking K, Kaleta C*, Schulenburg H*.  Front Microbiol. 10:1793. # Equal contribution as first authors, * Equal contribution as senior authors doi: 10.3389/fmicb.2019.01793.


The Saposin-Like Protein AplD Displays Pore-Forming Activity and Participates in Defense Against Bacterial Infection During a Multicellular Stage of Dictyostelium discoideum.

Dhakshinamoorthy R, Bitzhenner M, Cosson P, Soldati T, Leippe M (2018); Front. Cell. Infect. Microbiol., 8:73. doi: 10.3389/fcimb.2018.00073

The Caenorhabditis elegans proteome response to naturally associated microbiome members of the genus Ochrobactrum

Cassidy L, Petersen C, Treitz C, Dierking K, Schulenburg H, Leippe M, Tholey A (2018); Proteomics, doi: 10.1002/pmic.201700426

Miniaturized dispersive liquid-liquid microextraction and MALDI MS using ionic liquid matrices for the detection of bacterial communication molecules and virulence factors.

Leipert J, Bobis I, Schubert S, Fickenscher H, Leippe M, Tholey A (2018); Anal Bioanal Chem. , pp 1–12. doi: 10.1007/s00216-018-0937-6


Identification and Quantification of N-Acyl Homoserine Lactones Involved in Bacterial Communication by Small-Scale Synthesis of Internal Standards and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.

Leipert J, Treitz C, Leippe M, Tholey A (2017); J Am Soc Mass Spectrom., 28(12):2538-2547. doi: 10.1007/s13361-017-1777-x